T cells are an important component of the immune system. They play an essential role in fighting infections and cancer, but, unfortunately, they can also contribute to the development of several autoimmune diseases. Thus, there are stringent regulatory processes in place that accompany T cell development in the thymus as well as additional checkpoints that control mature T cell function. Dr. Melichar is interested in the mechanisms that maintain a functional and safe population of T cells. The focus of the research program is on the regulators of T cell activity and has important clinical implications. The team uses knowledge gained from these studies to develop new therapeutic discovery platforms and drugs to treat cancer.
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